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Autophagy (macroautophagy) is a catabolic process which targets intracellular components such as proteins and organelles for degradation. Originally described as a bulk degradation process, current research supports its selective nature (1). Selective autophagy targets specific cellular components for degradation including the endoplasmic reticulum (2) (ER-phagy), mitochondria (3) (mitophagy.
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NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC 50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.
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Nucleolin (NCL) is a 100-110-kDa protein that is ubiquitously expressed in exponentially growing eukaryotic cells ().Although more than 90% of NCL is found in the nucleolus, NCL has been divided into nuclear, cytoplasmic, and cell surface NCL, depending on location in the cells ().Reportedly, NCL has been targeted in preclinical and clinical trials of many cancers, including renal cell.
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Product Code: NCL-L-NOS-1 Intended Use For in vitro diagnostic use. NCL-L-NOS-1 is intended for the qualitative identification by light microscopy of human nitric oxide synthase-1 in paraffin sections. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should
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View Rabbit Monoclonal anti-Nucleolin Antibody (NCL/8068R) [mFluor Violet 500 SE] (NBP3-24068MFV500). Validated Applications: WB, IHC. Validated Species: Human.
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View Rabbit Monoclonal anti-Nucleolin Antibody (NCL/7014R) [PE] (NBP3-11038PE). Validated Applications: Flow. Validated Species: Human, + more.
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The antibody reacts with cow S-100 A and B, and crossreacts strongly with human S-100 A and B. The antibody also crossreacts with chicken, pig, kangaroo, dog, cat, monkey, mouse and rat S-100. Reagent Composition NCL-L-S100p is a liquid immunoglobulin fraction purified from rabbit serum diluted in PBS with 1% BSA containing sodium azide. Traces
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Recognizes a protein of ~76kDa, which is identified as Nucleolin (NCL). It is the major nucleolar phosphoprotein of growing eukaryotic cells. NCL is located mainly in dense fibrillar regions of the nucleolus. It is found associated with intranucleolar chromatin and pre-ribosomal particles. Human NCL gene consists of 14 exons with 13 introns and.
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Here we show that NCL-1/TRIM2/Brat tumour suppressor extends lifespan and limits nucleolar size in the major C. elegans longevity pathways, as part of a convergent mechanism focused on the.
